A man used to vicissitudes is not easily dejected.

饱经沧桑,不易沮丧.

《简明英汉词典》

In the course of ( ie During ) my long life I've known many changes.

我在漫长的一生中饱经沧桑.

辞典例句

The old man had experienced many vicissitudes of life.

这位老人饱经沧桑.

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He'd had a chequered past but was now determined to be successful.

他过去饱经沧桑,但现在决心要干一番成就.

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Is it any mystery that he hardened his heart, that he raised the emotional ramparts?

这是否很神秘,因为他的心那样饱经沧桑?

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Elmore is a rigger who has long been suffering harsh treatment from his family and neighbors.

艾蒙是个黑人穷小子,自幻遭邻居欺凌,被家人忽略,被女友抛弃,饱经沧桑.

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